AOD 9604 - 5MG

AOD 9604

AOD 9604 (6 mg) is a synthetic peptide fragment derived from the C-terminus of human growth hormone (HGH), engineered to target fat metabolism. Unlike full-length HGH, AOD 9604 is designed to promote lipolysis and inhibit lipogenesis without anabolic effects on muscle or impact on blood glucose.^[1][2]

In obese rodent models, chronic AOD 9604 reduced body weight and adiposity alongside increased β₃-adrenergic receptor RNA—enhancing adipose lipolytic sensitivity—independent of food intake. Acute dosing increases energy expenditure and fat oxidation.^[1][2]

Ex vivo and in vitro human adipose studies show increased lipolysis and decreased lipogenesis, supporting translational potential for obesity management. Unlike intact HGH, AOD 9604 does not induce insulin resistance or alter glucose metabolism, offering a fat-focused profile.^[2][1][3]

AOD 9604 does not promote muscle growth or other anabolic outcomes, focusing on selective fat reduction (e.g., stubborn abdominal depots) while preserving lean mass. Early-phase clinical development positions AOD 9604 as a promising anti-obesity agent with ongoing evaluation of efficacy and safety.^[1–3]

Summary: AOD 9604 (6 mg) targets fat loss by mimicking HGH’s lipolytic activity—enhancing fat breakdown and inhibiting new fat formation—without affecting muscle mass or glucose metabolism.^[1–3]

References

1. Heffernan M, Summers RJ, Thorburn A, et al. Endocrinology. 2001;142(12):5182–9. doi:10.1210/endo.142.12.8522.
2. Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. Am J Physiol Endocrinol Metab. 2000;279(3):E501–7. doi:10.1152/ajpendo.2000.279.3.E501.
3. Halford JC. Curr Opin Investig Drugs. 2006;7(4):312–8.

All COA’s avail upon request by email info@truformlabs.com.

Storage & Handling (Research Use)

• Lyophilized (dry) peptide: Store sealed at −20 °C (long-term). Short-term storage up to 2–3 weeks at 2–8 °C is acceptable.
• After reconstitution: Store at 2–8 °C and use within 7 days, or aliquot into sterile vials and freeze at −20 °C for up to 3 months.
• Light & moisture: Protect from light; keep container tightly closed to avoid moisture uptake.
• Freeze–thaw: Avoid repeated freeze–thaw cycles by preparing small aliquots.
• Solvent compatibility: Use a sterile, compatible solvent per your protocol; filter-sterilize if required.
• Labeling: Clearly label aliquots with concentration, solvent, and preparation date.

Storage guidance is general for research peptides and may be adapted to your lab SOP.