Cardio Cytogen - 20MG

Log in to view pricing Apply for provider account
Cardio Cytogen - 20MG
Availability:
In Stock

Product Overview

Cardio Cytogen

Cardioactive peptides are endogenous regulators and emerging therapeutics in cardiovascular disease (CVD). Key chromogranin A (CgA)–derived peptides—catestatin, vasostatin, and chromofungin—are released from the sympathoadrenal system and myocardium and modulate cardiac contractility, vascular tone, and ischemia/reperfusion (I/R) tolerance.[1–3]

Mechanisms of Cardioprotection

  • Catestatin & Vasostatin: Negative inotropic/lusitropic effects, feedback inhibition of catecholamine release, and protection from sympathetic overstimulation. Vasostatin can trigger preconditioning (pre-ischemia), while catestatin acts as a postconditioning agent (at reperfusion), engaging NO-dependent prosurvival signaling (PI3K/Akt → eNOS) via endothelium-dependent and direct myocardial actions; effects may be partly receptor-independent.[1,2]
  • Chromofungin (CgA47–66): Induces negative inotropy through AKT/eNOS/cGMP/PKG and confers postconditioning cardioprotection (↓ infarct size, ↓ LDH) during I/R via PI3K, RISK cascade, mitoKATP channels, and miR-21.[3]

Cardiomyopeptides & Mitochondrial Protection

  • Cardiomyopeptides (CMPs): Upregulate PPARγ, preserve mitochondrial integrity/respiration, and reduce myocardial injury and inflammation in I/R models (↓ AST, Mb, cTnT), limiting post-ischemic damage.[4]

Broader Peptide Therapeutics in CVD

  • Atherosclerosis/Inflammation/Metabolism: ApoA-I/apoE mimetics, SOCS1-derived peptides, annexin-A1, and incretin mimetics target lipid transport, inflammation, and glucose-insulin tolerance.[5]
  • Dietary/endogenous peptides: Animal/plant-derived peptides exhibit anti-inflammatory, antihypertensive, and anti-atherosclerotic activities, supporting nutrition-based prevention strategies.[6,7]

Targeting & Delivery

  • Cardiac-Targeting Peptides (CTPs): Cell-penetrating/cardiac-homing sequences improve myocardial delivery and therapeutic index in preclinical models.[8]

Clinical & Translational Implications

  • Endogenous/synthetic peptides (e.g., neuregulin-1, angiotensin-(1-9), growth/differentiation factors, IGF-1) are under evaluation for reducing cardiomyocyte death and preserving function post-injury.[9]
  • Discovery across vertebrate/invertebrate systems highlights conserved peptidergic regulation of cardiac physiology and its translational relevance.[10]

Key Takeaways

  • CgA-derived peptides (catestatin, vasostatin, chromofungin) counter I/R injury via NO-dependent and PI3K/Akt pathways and modulation of mitochondrial and ECM signaling.[1–3]
  • CMPs bolster mitochondrial resilience and dampen myocardial injury/inflammation in I/R.[4]
  • Therapeutic horizon: Targeted delivery and peptide/polypeptidomimetic design are expanding options for cardioprotection and remodeling.[5,8,9]

References

  1. Penna C, Tullio F, Perrelli MG, Mancardi D, Pagliaro P. Curr Med Chem. 2012;19(24):4074-85. doi:10.2174/092986712802429966.[1]
  2. Fornero S, Bassino E, Gallo MP, et al. Curr Med Chem. 2012;19(24):4059-67. doi:10.2174/092986712802429984.[2]
  3. Filice E, Pasqua T, Quintieri AM, et al. Peptides. 2015;71:40-48. doi:10.1016/j.peptides.2015.06.013.[3]
  4. Guo Z, Qian G, Pan X, et al. Int J Med Sci. 2025;22(1):44-52. doi:10.7150/ijms.102763.[4]
  5. Recio C, Maione F, Iqbal AJ, Mascolo N, De Feo V. Front Pharmacol. 2016;7:526. doi:10.3389/fphar.2016.00526.[5]
  6. Cam A, de Mejia EG. Mol Nutr Food Res. 2012;56(1):53-66. doi:10.1002/mnfr.201100535.[6]
  7. Li W, Lv M, Zhang T, et al. J Agric Food Chem. 2023;71(40):14562-14574. doi:10.1021/acs.jafc.3c02339.[7]
  8. Sahagun D, Zahid M. Biomolecules. 2023;13(12):1690. doi:10.3390/biom13121690.[8]
  9. Garrido V, Mendoza-Torres E, Riquelme JA, et al. Curr Pharm Des. 2017;23(18):2592-2615. doi:10.2174/1381612823666170112122637.[9]
  10. Schiemann R, Lammers K, Janz M, et al. Int J Mol Sci. 2018;20(1):E2. doi:10.3390/ijms20010002.[10]

All information provided is for research purposes only.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.