GHK-Cu - 100MG

GHK-Cu

GHK-Cu (glycyl-L-histidyl-L-lysine copper) is an endogenous tripeptide–copper complex with broad regenerative and reparative properties. GHK is present in plasma, saliva, and urine, but levels decline with age. GHK-Cu forms via high-affinity binding of GHK to copper(II), a physiologically relevant process for wound healing and skin regeneration.^[1–4]

Mechanism of Action & Cellular Effects

• Modulates skin-regeneration pathways: stimulates collagen, elastin, glycosaminoglycan, and decorin; regulates MMPs and their inhibitors.^[1][5–7]
• Promotes dermal fibroblast/keratinocyte proliferation and migration, enhances angiogenesis (VEGF activation), and recruits immune/endothelial cells to injury sites.^{[1][3–5][8–10]}
• Anti-inflammatory/antioxidant: suppresses free radicals, thromboxane, and pro-inflammatory cytokines; increases SOD and vasodilation.^[3][11]
• Gene modulation: up-/down-regulates thousands of human genes involved in DNA repair, proteasome activation, and suppression of tissue-destructive/cancer-promoting genes.^[2][5][11]

Clinical & Translational Evidence

• Accelerates healing in skin, hair follicles, GI tract, bone, and other tissues in animal and human studies.^{[1][3–6][8–10]}
• In aged skin: improves tightness, elasticity, density, firmness; reduces fine lines, wrinkles, photodamage, and hyperpigmentation.^[1][3][12]
• Increases integrin expression and p63 positivity in keratinocytes → supports stem-cell survival and barrier repair.^[4][12]
• Advanced delivery (nanoengineered/liposomal) enhances stability, bioactivity, and wound-healing efficacy.^[8–10]
• Protective effects in models of liver injury, GI ulcers, and bone healing; under investigation for skin inflammation, COPD, and metastatic colon cancer.^[1–5]

Safety & Tolerability

• Long history of safe use in wound care and skincare with no significant adverse effects in clinical/preclinical studies.^[1][11][12]

Summary: GHK-Cu (100 mg) is a multifunctional peptide–copper complex that accelerates wound healing, drives tissue regeneration, reduces inflammation/oxidative stress, and broadly shifts gene expression toward a reparative phenotype—supporting uses across dermatology, regenerative medicine, and potential systemic applications.^[1–12]

References

1. Pickart L, Vasquez-Soltero JM, Margolina A. Biomed Res Int. 2015:648108.
2. Pickart L, Vasquez-Soltero JM, Margolina A. Biomed Res Int. 2014:151479.
3. Pickart L. J Biomater Sci Polym Ed. 2008;19(8):969-88.
4. Kang YA, Choi HR, Na JI, et al. Arch Dermatol Res. 2009;301(4):301-6.
5. Pickart L, Margolina A. Int J Mol Sci. 2018;19(7):E1987.
6. Siméon A, Wegrowski Y, Bontemps Y, Maquart FX. J Invest Dermatol. 2000;115(6):962-8.
7. Siméon A, Emonard H, Hornebeck W, Maquart FX. Life Sci. 2000;67(18):2257-65.
8. Lee S, Lee SM, Lee SH, et al. Acta Biomater. 2023;172:159-174.
9. Castro VIB, Araújo AR, Reis RL, et al. ACS Appl Mater Interfaces. 2025;17(8):11624-11633.
10. Wang X, Liu B, Xu Q, et al. Wound Repair Regen. 2017;25(2):270-278.
11. Pickart L, Vasquez-Soltero JM, Margolina A. Oxid Med Cell Longev. 2012:324832.
12. He B, Wang F, Qu L. Front Pharmacol. 2023;14:1267765.

All COA’s avail upon request by email info@truformlabs.com.

Storage & Handling (Research Use)

• Lyophilized (dry) peptide: Store sealed at −20 °C (long-term). Short-term up to 2–3 weeks at 2–8 °C is acceptable.
• After reconstitution: Store at 2–8 °C and use within 7 days, or aliquot into sterile vials and freeze at −20 °C for up to 3 months.
• Light & moisture: Protect from light; keep container tightly closed to avoid moisture uptake.
• Freeze–thaw: Avoid repeated freeze–thaw cycles (prepare aliquots).
• Solvent compatibility: Use a sterile, compatible solvent per your protocol; filter-sterilize if required.
• Labeling: Clearly label aliquots with concentration, solvent, and preparation date.

Storage guidance is general for research peptides and may be adapted to your lab SOP.