Kisspeptin 10 - 5MG

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Kisspeptin 10 - 5MG
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Product Overview

Kisspeptin 10

Kisspeptin is a hypothalamic neuropeptide that drives the hypothalamic–pituitary–gonadal (HPG) axis by activating GnRH neurons via the kisspeptin receptor KISS1R. ARC KNDy (kisspeptin/neurokinin B/dynorphin) neurons serve as the physiological GnRH pulse generator, integrating sex-steroid feedback and metabolic inputs.[1–6]

Reproductive Physiology & Clinical Applications

  • Essential for puberty, menstrual cyclicity, ovulation, and fertility in all sexes; loss-of-function causes congenital hypogonadotropic hypogonadism and infertility.[1–6]
  • Exogenous kisspeptin acutely stimulates LH/FSH secretion and LH pulse frequency in healthy adults and in hypothalamic amenorrhea/hypogonadotropic hypogonadism.[2–6,9,10]
  • IVF applications: kisspeptin-based oocyte maturation protocols show physiologic GnRH-axis activation with reduced OHSS risk versus hCG in early studies.[7–10]
  • Functional hypogonadism & diagnostics: chronic/serial dosing is under investigation to restore reproductive function; diagnostic utility explored for delayed puberty and hypothalamic disorders.[7–10]

Metabolic & Behavioral Effects

  • Energy balance: KISS1/KISS1R are expressed in adipose, pancreas, liver, and BAT; knockout models show increased adiposity and reduced energy expenditure.[3,11,12]
  • Glucose homeostasis: data suggest potentiation of glucose-stimulated insulin secretion and weight-modulatory, sexually dimorphic effects.[11,12]
  • Additional roles: sexual behavior/attraction circuits, placental function, and bone health have emerging evidence.[1,3,8,11]

Therapeutic Potential & Safety

  • Analog development: longer-acting kisspeptin analogs aim to overcome short half-life and tachyphylaxis for sustained GnRH drive.[7,8,10]
  • Targets: reproductive disorders (hypogonadism, hypothalamic amenorrhea, PCOS) and hypothalamic function testing.[7–10]
  • Safety: favorable profile in clinical studies at physiologic/pharmacologic doses; significant adverse effects uncommon to date.[7–10]

Key Takeaways

  • Master HPG regulator: KNDy-driven GnRH pulse generation underpins puberty and fertility.
  • Clinical momentum: acute LH/FSH stimulation, IVF triggering strategies, and diagnostic applications are advancing.
  • Beyond reproduction: metabolic and behavioral effects broaden translational potential.

References

  1. Koysombat K, Tsoutsouki J, Patel AH, et al. Physiol Rev. 2025;105(2):707–764. doi:10.1152/physrev.00015.2024.[1]
  2. Xie Q, Kang Y, Zhang C, et al. Front Endocrinol. 2022;13:925206. doi:10.3389/fendo.2022.925206.[2]
  3. Harter CJL, Kavanagh GS, Smith JT. J Endocrinol. 2018;238(3):R173–R183. doi:10.1530/JOE-18-0108.[3]
  4. Ruohonen ST, Poutanen M, Tena-Sempere M. Fertil Steril. 2020;114(3):465–474. doi:10.1016/j.fertnstert.2020.06.038.[4]
  5. Skorupskaite K, George JT, Anderson RA. Hum Reprod Update. 2014;20(4):485–500. doi:10.1093/humupd/dmu009.[5]
  6. Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M. Physiol Rev. 2012;92(3):1235–1316. doi:10.1152/physrev.00037.2010.[6]
  7. Abbara A, Clarke SA, Dhillo WS. Trends Mol Med. 2021;27(8):807–823. doi:10.1016/j.molmed.2021.05.008.[7]
  8. Patel B, Koysombat K, Mills EG, et al. Endocr Rev. 2024;45(1):30–68. doi:10.1210/endrev/bnad023.[8]
  9. Hunjan T, Abbara A. Semin Reprod Med. 2019;37(3):119–124. doi:10.1055/s-0039-3400240.[9]
  10. Tsoutsouki J, Abbara A, Dhillo W. Curr Opin Pharmacol. 2022;67:102319. doi:10.1016/j.coph.2022.102319.[10]
  11. Izzi-Engbeaya C, Dhillo WS. J Physiol. 2022;600(5):1079–1088. doi:10.1113/JP281712.[11]
  12. Hudson AD, Kauffman AS. Pharmacol Ther. 2022;231:107974. doi:10.1016/j.pharmthera.2021.107974.[12]

All information provided is for research purposes only.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.