Livagen

Compound: Livagen (Lys-Glu-Asp-Ala)—20 mg vial, lyophilized.

MW: ~461.5 g/mol; a short bioregulatory peptide with epigenetic and immune-modulating potential :contentReference[oaicite:1]{index=1}.

For research use only—NOT for human or veterinary use.

Batch-purity ≥ 98–99%; COA available on request—email providers@theratideusa.com.

• Epigenetic modulation: Livagen induces chromatin de‑condensation in lymphocytes, reactivating silent genes—ribosomal and DNA-repair—especially in aged models :contentReference[oaicite:2]{index=2}.
• Immune activation: Restores youthful protein synthesis in rat hepatocytes and enhances lymphocyte gene expression :contentReference[oaicite:3]{index=3}.
• Pain & opioid regulation: Inhibits enkephalin-degrading enzymes (IC₅₀ ~20 µM), raising endogenous pain modulators without direct receptor agonism :contentReference[oaicite:4]{index=4}.
• Gastro‑protection & digestion: Modulates GI enzymes and vagal signaling; increases mucosal nitric oxide and prostaglandin—beneficial for GI integrity in aged rat models :contentReference[oaicite:5]{index=5}.
• Cardio‑protection: Epigenetic effects on lymphocytes may reduce cardiac inflammation and fibrosis signals in hypertrophic models :contentReference[oaicite:6]{index=6}.

Most evidence is preclinical or in vitro; human data remain limited.

What is Livagen used for in research?
It’s used for studying epigenetic rejuvenation, immune restoration, gastro‑protection, pain modulation, and cardio‑repair :contentReference[oaicite:7]{index=7}.

How does it affect chromatin?
It promotes de‑heterochromatinization, reactivating age-silenced genes in immune cells :contentReference[oaicite:8]{index=8}.

Can it relieve pain?
By inhibiting enkephalin-degrading enzymes, it elevates natural pain-relief peptides; no direct receptor binding :contentReference[oaicite:9]{index=9}.

Any safety data?
Animal and in vitro studies show low toxicity; human toxicology data are not available.

Recommended storage?
Keep lyophilized vials at ≤ –20 °C; reconstitute freshly before use.

For laboratory research use only—not for human or veterinary use, nor as a dietary supplement.

Safety: Follow appropriate lab protocols and storage procedures.

FDA Notice: Not evaluated by FDA. Not intended to diagnose, treat, cure, or prevent any disease.