Product Overview
Compound: MIF‑1 (Pro‑Leu‑Gly‑NH₂), also called melanostatin or PLG
Format: 10 mg, 50 mg vials (lyophilized)
For research use only—NOT for human or veterinary use.
Each batch is third‑party tested for ≥98 % purity. COAs are available upon request—email providers@theratideusa.com.
- Endogenous neuropeptide: Cleaved from oxytocin in the hypothalamus and inhibits MSH release :contentReference[oaicite:1]{index=1}.
- Dopamine modulator: Acts as an allosteric modulator of D₂/D₄ receptors; influences monoamines :contentReference[oaicite:2]{index=2}.
- Opioid activity: Exhibits both opiate‑antagonist and agonist effects; studied in anti‑opiate systems :contentReference[oaicite:3]{index=3}.
- Antidepressant potential: Early clinical trials showed rapid mood improvement; animal and human studies indicate antidepressant effects :contentReference[oaicite:4]{index=4}.
- Neuroprotective/CNS activity: Activates multiple brain regions via pERK, pSTAT3, and c‑Fos signaling—implicated in Parkinson’s and depression models :contentReference[oaicite:5]{index=5}.
- Memory & motor support: Enhances learning, neuromotor behavior, and memory in animal models :contentReference[oaicite:6]{index=6}.
Research largely preclinical; human data remain limited but promising.
What is MIF‑1 studied for?
It's researched for depression, Parkinson’s, neuromodulation, motor function, and stress resilience :contentReference[oaicite:7]{index=7}.
How does it work?
It modulates dopamine receptors (D₂/D₄), affects opioid systems, inhibits MSH, and triggers neuro signaling cascades :contentReference[oaicite:8]{index=8}.
Any human evidence?
Small-scale trials (~60 mg/day) reported rapid antidepressant responses in 4 of 5 participants within 2–3 days :contentReference[oaicite:9]{index=9}.
Delivery & dosage?
Not orally active; typically administered via injection in research contexts.
Side effects?
Generally minimal in reported studies; safety data still limited.
For laboratory research use only—not for human or veterinary use, nor as a dietary supplement.
Safety: Handle only under standard lab protocols; store securely.
FDA Notice: These statements have not been evaluated by the FDA; not intended to diagnose, treat, cure, or prevent any disease.
