TB-500 {Thymosin Beta 4 Fragment 17-23} 5MG

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TB-500 {Thymosin Beta 4 Fragment 17-23} 5MG
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Product Overview

TB-500 (Tβ4 17–23)

TB-500 corresponds to residues 17–23 (LKKTETQ) of Thymosin Beta 4 (Tβ4)—the core actin-binding motif essential for G-actin sequestration, regulation of actin polymerization, and downstream control of cell motility, migration, and angiogenesis. The 17–23 fragment recapitulates many biological effects of full-length Tβ4 in vitro and in vivo.[1–3]

Endothelial Activation & Angiogenesis

  • Promotes endothelial cell migration, adhesion, and tubule formation; stimulates aortic ring sprouting and angiogenesis at nanomolar concentrations.[3]
  • Loss of the LKKTETQ region abrogates activity in migration/angiogenesis assays, confirming it as the primary active site.[3]
  • Accelerates re-epithelialization, enhances angiogenesis, and reduces inflammation/scarring in dermal and corneal wound models (parent Tβ4 and active fragments).[4–7]

Pharmacokinetics & Active Metabolites

  • TB-500 is metabolized in vivo to shorter peptides; Ac-LKKTE identified as a metabolite with significant wound-healing activity in fibroblast assays; no in-vitro cytotoxicity observed for TB-500 or its metabolites.[8]

Anti-Inflammatory & Anti-Fibrotic Context

  • The N-terminal Tβ4 motif Ac-SDKP (distinct from 17–23) is linked to anti-inflammatory/anti-fibrotic effects, while the central LKKTETQ motif chiefly mediates angiogenesis and migration—together underpinning Tβ4’s pleiotropy.[2,9]

Clinical & Translational Landscape

  • Ongoing research explores Tβ4/TB-500 in wound care, ocular surface repair, and cardiovascular tissue protection/regeneration, supported by mechanistic and preclinical efficacy data.[10–15,4–7,12]

Key Takeaways

  • Active-site fragment: LKKTETQ (17–23) is the validated actin-binding/angiogenic core of Tβ4.[2,3]
  • Nanomolar potency: Drives endothelial migration and tubulogenesis; supports rapid wound closure.[3–7]
  • Metabolite contribution: Ac-LKKTE exhibits wound-healing activity; non-cytotoxic in vitro.[8]
  • Complementary domains: Anti-fibrotic actions (Ac-SDKP) complement the pro-repair LKKTETQ axis.[2,9]

References

  1. Ying Y, et al. Curr Protein Pept Sci. 2023;24(1):78-88. doi:10.2174/1389203724666221201093500.[1]
  2. Sosne G, et al. FASEB J. 2010;24(7):2144-2151. doi:10.1096/fj.09-142307.[2]
  3. Philp D, et al. FASEB J. 2003;17(14):2103-2105. doi:10.1096/fj.03-0121fje.[3]
  4. Treadwell T, et al. Ann N Y Acad Sci. 2012;1270:37-44. doi:10.1111/j.1749-6632.2012.06717.x.[4]
  5. Yang WS, et al. Eur J Dermatol. 2019;29(5):459-467. doi:10.1684/ejd.2019.3642.[5]
  6. Goldstein AL, et al. Expert Opin Biol Ther. 2012;12(1):37-51. doi:10.1517/14712598.2012.634793.[6]
  7. Kleinman HK, Sosne G. Vitam Horm. 2016;102:251-275. doi:10.1016/bs.vh.2016.04.005.[7]
  8. Rahaman KA, et al. J Chromatogr B. 2024;1235:124033. doi:10.1016/j.jchromb.2024.124033.[8]
  9. Renga G, et al. Expert Opin Biol Ther. 2018;18(sup1):171-175. doi:10.1080/14712598.2018.1473854.[9]
  10. Xing Y, et al. Front Endocrinol. 2021;12:767785. doi:10.3389/fendo.2021.767785.[10]
  11. Goldstein AL, Kleinman HK. Expert Opin Biol Ther. 2015;15(S1):S139-S145. doi:10.1517/14712598.2015.1011617.[11]
  12. Hinkel R, et al. Ann N Y Acad Sci. 2012;1269:102-109. doi:10.1111/j.1749-6632.2012.06693.x.[12]
  13. Crockford D, et al. Ann N Y Acad Sci. 2010;1194:179-189. doi:10.1111/j.1749-6632.2010.05492.x.[13]
  14. Bjørklund G, et al. Curr Med Chem. 2020;27(37):6294-6305. doi:10.2174/0929867326666190716125456.[14]
  15. Philp D, Kleinman HK. Ann N Y Acad Sci. 2010;1194:81-86. doi:10.1111/j.1749-6632.2010.05479.x.[15]

All information provided is for research purposes only.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.