Thymalin - 100MG

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Thymalin - 100MG
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Product Overview

Thymalin: Immunoregulatory Peptide Complex

Thymalin is a thymic peptide complex with established immunoregulatory, anti-aging, and cellular rejuvenation actions. Core activity includes stimulation of T-cell differentiation/maturation and modulation of cytokine and inflammatory pathways; it has been used clinically as an immunomodulator in several countries.[1,2]

Immune Regulatory Effects

  • Promotes T-cell differentiation, maturation, proliferation, and cytokine production, strengthening adaptive immunity in immunosenescence, thymic hypoplasia, recurrent infections, and oncology settings.[1,2]
  • In vitro, Thymalin/thymic peptides modulate monocyte/macrophage proliferation and inflammation, reducing TNF and IL-6 and decreasing adhesion to activated endothelium.[3]

Anti-Aging & Geroprotective Outcomes

  • Long-term studies in elderly cohorts report normalization of cardiovascular, endocrine, immune, and nervous system function with fewer ARIs, IHD, hypertension, osteoarthritis, and osteoporosis events.[4]
  • Observed mortality reduction up to 2.0–2.1× vs controls with Thymalin alone and up to 4.1× when combined with pineal peptides.[4]
  • Geroprotective actions attributed to restoration of thymic output and reversal of immunosenescence.[2,4]

Cellular Rejuvenation & Inflammatory Modulation

  • Regulates MAPK-linked tyrosine phosphorylation and suppresses pro-inflammatory cytokines in innate immune cells; attenuates NF-κB/MAPK/PKC-θ signaling and reduces lymphocyte apoptosis in chronic inflammation models.[3,7]
  • Related thymic peptides (e.g., thymulin) show anti-inflammatory/analgesic CNS and peripheral effects; gene therapy restoration of thymic peptides prevents neuroendocrine/metabolic abnormalities in deficiency states.[5–7]

Clinical Applications & Safety

  • Used as an adjunct immunomodulator for immunodeficiency, autoimmune disease, infections, and supportive oncology; also applied to mitigate immunosenescence and enhance healthspan in aging populations.[1,2,4]
  • Extensive preclinical and clinical experience reports favorable tolerability without significant long-term adverse effects.[1,4]

Key Takeaways

  • Restores immune competence via T-cell maturation and cytokine balance.
  • Geroprotective signal with reported multi-system normalization and reduced mortality in elderly cohorts.
  • Inflammation control through NF-κB/MAPK pathway modulation and apoptosis regulation.

References

  1. Rodriguez Martin RR, et al. Int Immunopharmacol. 2023;119:110167. doi:10.1016/j.intimp.2023.110167.[1]
  2. Khavinson VKh. Neuro Endocrinol Lett. 2002;23(Suppl 3):11-144.[2]
  3. Avolio F, et al. Int J Mol Sci. 2022;23(7):3607. doi:10.3390/ijms23073607.[3]
  4. Khavinson VKh, Morozov VG. Neuro Endocrinol Lett. 2003;24(3-4):233-240.[4]
  5. Reggiani PC, et al. Curr Pharm Des. 2014;20(29):4690-4696.[5]
  6. Reggiani PC, et al. Ann NY Acad Sci. 2009;1153:98-106.[6]
  7. Novoselova EG, et al. PLoS One. 2018;13(5):e0197601. doi:10.1371/journal.pone.0197601.[7]

All information provided is for research purposes only.

ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY. The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease. Bodily introduction of any kind into humans or animals is strictly forbidden by law.