Wolverine Blend (BPC-157/10MG - TB-500/10MG)

Wolverine Blend • Synergistic BPC-157 (10 mg) + TB500 (10 mg)

A synergistic blend of BPC-157 and TB500 designed to leverage complementary regenerative and anti-inflammatory properties for advanced tissue repair and optimal recovery.

BPC-157

Stable gastric pentadecapeptide with broad evidence for accelerating healing in skin, muscle, tendon, ligament, bone, nerve, and GI tissues. Promotes angiogenesis, enhances fibroblast/endothelial migration, and upregulates growth hormone receptor in tendon fibroblasts. Modulates the nitric oxide (NO) system to improve vasodilation, blood flow, and tissue oxygenation, with anti-inflammatory actions via suppression of pro-inflammatory cytokines and oxidative stress and restoration of tissue homeostasis.^[1–11]

TB500 (thymosin β4)

Multifunctional peptide supporting repair by promoting cell migration, angiogenesis, and stem-cell maturation. Downregulates inflammatory chemokines/cytokines, enhances neovascularization, and accelerates wound healing across dermal, corneal, cardiac, and musculoskeletal tissues. Actin-sequestering properties facilitate cytoskeletal remodeling essential for regeneration after injury.^[12–13]

Synergistic Mechanisms & Clinical Implications

• Advanced Tissue Repair: Dual targeting of inflammation resolution, cell migration, angiogenesis, and matrix remodeling. BPC-157’s GHR upregulation in tendon fibroblasts may potentiate TB500’s regenerative effect.^[9,12–13]
• Reduced Inflammation: Both peptides suppress pro-inflammatory cytokines/chemokines, reduce oxidative stress, and promote balanced immune responses to speed resolution and minimize fibrosis.^{[6–7,12–13]}
• Optimal Recovery: Preclinical models show accelerated recovery from musculoskeletal injury, improved function, and shortened downtime with minimal reported adverse effects.^{[1–5,12–13]}

Safety

Both peptides demonstrate favorable safety profiles in preclinical and early clinical literature; BPC-157 reports no toxicity at therapeutic ranges, and TB500 is well tolerated in ongoing clinical work.^{[1–5,12–14]}

References

1. Seiwerth S, Milavic M, Vukojevic J, et al. Front Pharmacol. 2021;12:627533.
2. Gwyer D, Wragg NM, Wilson SL. Cell Tissue Res. 2019;377(2):153-159.
3. Seiwerth S, Rucman R, Turkovic B, et al. Curr Pharm Des. 2018;24(18):1972-1989.
4. Sikiric P, Seiwerth S, Brcic L, et al. Curr Pharm Des. 2010;16(10):1224-1234.
5. Sikiric P, Drmic D, Sever M, et al. Curr Pharm Des. 2020;26(25):2991-3000.
6. Sikiric P, Seiwerth S, Rucman R, et al. Curr Pharm Des. 2017;23(27):4012-4028.
7. Sikiric P, Seiwerth S, Skrtic A, et al. Pharmaceuticals. 2025;18(6):928.
8. Lojo N, Rasic Z, Zenko Sever A, et al. PLOS ONE. 2016;11(9):e0162590.
9. Chang CH, Tsai WC, Hsu YH, Pang JH. Molecules. 2014;19(11):19066-77.
10. Sikiric P, Seiwerth S, Rucman R, et al. Curr Neuropharmacol. 2016;14(8):857-865.
11. Hsieh MJ, Lee CH, Chueh HY, et al. Sci Rep. 2020;10:17078.
12. Philp D, Kleinman HK. Ann N Y Acad Sci. 2010;1194:81-86.
13. Goldstein AL, Kleinman HK. Expert Opin Biol Ther. 2015;15(S1):S139-145.
14. Józwiak M, Bauer M, Kamysz W, Kleczkowska P. Pharmaceuticals. 2025;18(2):185.

All COA’s avail upon request by email info@truformlabs.com.

Storage & Handling (Research Use)

• Lyophilized (dry) vials: Store sealed at −20 °C (long-term), desiccated and protected from light. Short-term (≤2–3 weeks) at 2–8 °C is acceptable.
• After reconstitution: Store at 2–8 °C and use within 7 days, or aliquot and freeze at −20 °C for up to 3 months.
• Avoid freeze–thaw: Prepare small aliquots to prevent repeated cycles.
• Solvent: Reconstitute per protocol (e.g., sterile saline/bacteriostatic water). For blends, avoid strong chelators that could impact peptide complexes.
• Handling: Keep solutions on ice during use; discard any unused thawed aliquots.
• Labeling: Mark concentration, solvent, and prep date on all aliquots.

General peptide-blend guidance; follow your lab’s SOPs and product-specific stability data when available.